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What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
Hirsch S, de la Maza MP, Gattas V, et al
Taurine concentrations in congestive heart failure
Oxidative stress has been reported to significantly affect female reproduction via lipid peroxidation in oocytes [45]
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